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ISCC Blog

Hydroxyurea: did you Know?

11/16/2017

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People with sickle cell disease (SCD) make hemoglobin S. This hemoglobin stretches out the red blood cells (also called “sickling”). Sickled red blood cells have trouble moving through the blood vessels and can cause pain and organ damage. Hydroxyurea helps people with SCD by increasing the amount of Hemoglobin F in the body. Hemoglobin F helps keep red blood cells from sickling, so it can prevent some problems caused by SCD.
 
Hydroxyurea has been studied for decades to see how it can help people with SCD. There are several benefits that have been discovered. These include:
  • Fewer pain episodes, or crises, in patients taking hydroxyurea
  • Less need for blood transfusions
  • Fewer trips to the hospital
  • Fewer episodes of acute chest syndrome
    • Acute chest syndrome can include symptoms like shortness of breath, chest pain, fever, or coughing
  • When children take hydroxyurea, it may help prevent organ damage that is common in sickle cell disease. It may also help children’s spleens to continue functioning for a longer period of time
  • Hydroxyurea also lowers the risk of death in patients with SCD
 
Hydroxyurea has been used in patients with SCD for over 30 years. Research has shown that hydroxyurea is a safe and effective medication. People with SCD can start taking it as young as 9 months of age. If you have questions about hydroxyurea, please talk to your or your child’s hematologist.

Dr. Clark Kramer
Merrillville, Indiana
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  • Blog
  • Patient Information
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    • Resources
    • Find a Provider
    • Hemoglobin Traits
    • Comprehensive Care
    • Peds to Adults
    • School and Career
  • Provider Information
    • Continuing Education
    • Sickle Cell Resources
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  • Community Based Organizations
  • Contact Us
  • COVID-19 Vaccine
    • Frequently Asked Questions
    • Helpful Links
    • More About Vaccine Trials
  • Clinical Trials